Serum total homocysteine, folate, 5,10-methylenetetrahydrofolate reductase (MTHFR) 677CÆT genotype and subclinical atherosclerosis
Published in : Expert Opin. Ther. Targets Volume 313 May 2009 Pages 709
May 2009

Objective: To determine the relationship of serum total homocysteine (tHcy), serum folate and 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T genotype with ultrasonic arterial wall...

Vitamin D and the vasculature: can we teach an old drug new tricks?
Published in : Expert Opin. Ther. Targets Volume 76 May 2009 Pages 107
May 2009

Background: Vitamin D is a steroid hormone known for its role in regulating levels of calcium and phosphorus. Vitamin D has important autocrine/paracrine roles and it is involved in vascular biology....

Regulation of the Na+/H+ exchanger in the healthy and diseased myocardium
Published in : Expert Opin. Ther. Targets Volume 37 May 2009 Pages 33
May 2009

Background: Na + /H + exchangers (NHE's) are membrane proteins that regulate ion fluxes, they extrude one intracellular proton in exchange for one extracellular sodium thereby regulating...

Could rusalatide acetate be the future drug of choice for diabetic foot ulcers and fracture repair?
Published in : Expert Opin. Pharmacother. Volume 176 May 2009 Pages 80S
May 2009

Rusalatide acetate (Chrysalin ® ) is an investigational drug being evaluated for treatment of chronic wounds and fractures. Rusalatide acetate interacts with cell surface receptors to stimulate a...

Pharmacotherapy of age-related macular degeneration
Published in : Expert Opin. Pharmacother. Volume 114 May 2009 Pages 92
May 2009

Background: Age-related macular degeneration is the leading cause of blindness in the developed world. The number of persons with vision loss from age-related macular degeneration is projected to...

Management of the side effects of androgen deprivation therapy in men with prostate cancer
Published in : Expert Opin. Pharmacother. Volume 58 May 2009 Pages 71
May 2009

Background: Androgen deprivation therapy is the foundation of the medical management of prostate cancer. Androgen deprivation therapy offers improved efficacy when used with local therapy such as...

Clindamycin phosphate/tretinoin gel formulation in the treatment of acne vulgaris
Published in : Expert Opin. Pharmacother. Volume 196 May 2009 Pages 108
May 2009

Clindamycin phosphate 1.2% together with tretinoin 0.025% as a gel (CTG) is a topical formulation of a fixed and stable combination approved by the FDA for the treatment of acne vulgaris in patients...

Topical diclofenac: clinical effectiveness and current uses in osteoarthritis of the knee and soft tissue injuries
Published in : Expert Opin. Pharmacother. Volume 20 May 2009 Pages 508
May 2009

Background: Diclofenac is a commonly used non-steroidal anti-inflammatory drug (NSAID) for symptom control in osteoarthritis (OA) of the knee and soft tissue injuries. Although treatment with oral...

Pharmacotherapy of pneumonia occurring in older patients
Published in : Expert Opin. Pharmacother. Volume 160 May 2009 Pages 923
May 2009

The elderly population is characterized by several baseline conditions that increase the risk and modify the etiology of pneumonia. Immunosuppression caused by either concomitant morbidities or...

Prasugrel: a novel platelet ADP P2Y₁₂ receptor antagonist. A review on its mechanism of action and clinical development
Published in : Expert Opin. Pharmacother. Volume 82 May 2009 Pages 47
May 2009

Antiplatelet therapy is the cornerstone of treatment for patients who present with acute coronary syndrome (ACS) or undergo percutaneous coronary intervention (PCI). Clopidogrel, in combination with...

New perspectives for the treatment options in spinal cord injury
Published in : Expert Opin. Pharmacother. Volume 76 May 2009 Pages 319
May 2009

Spinal cord injury (SCI) is a serious clinical disorder that leads to lifetime disability for which no suitable therapeutic agents are available so far. Further research is needed to understand the...

Ciprofloxacin 0.3%/dexamethasone 0.1% topical drops for the management of otic infections
Published in : Expert Opin. Pharmacother. Volume 134 May 2009 Pages S4
May 2009

The American Academy of Otolaryngology – Head and Neck Surgery has recommended that, where possible, infections of the external auditory canal and middle ear be treated with topical preparations. The...

Managing neoplastic bone disease with ibandronic acid: a preclinical and clinical data update
Published in : Expert Opin. Pharmacother. Volume 11 May 2009 Pages 27
May 2009

Background: Bisphosphonates are the standard of care for treating and preventing the complications of bone metastases. Ibandronic acid is available in effective and well-tolerated oral (50 mg daily)...

Beneficial acute antidepressant effects of aripiprazole as an adjunctive treatment or monotherapy in bipolar patients unresponsive to mood stabilizers: results from a 16-week open-label trial
Published in : Expert Opin. Pharmacother. Volume 8 May 2009 Pages 1001
May 2009

Objective: Several lines of research suggested that aripiprazole might be a useful treatment for acute bipolar depression. The aim of this open-label trial is to give more evidence of the clinical...

Calcineurin inhibitors for the treatment of atopic dermatitis
Published in : Expert Opin. Pharmacother. Volume 128 May 2009 Pages 1067
May 2009

Background: Atopic dermatitis (AD) is a chronic disease characterized by periods of remission and relapse. Therapeutic objectives for AD should be to quickly reduce disease symptoms by targeting...