March 2010
Authors : Leonid M Berezhkovskiy
Affliation : Genetech Inc., 1 DNA Way, South San Francisco, CA 94080, USA ; ; berezhkovskiy.leo@gene.com
DOI : 10.1517/17425250802503808
Published in : Expert Opin. Drug Metab. Toxicol.
Subject: Review
Keywords: affinity , albumin , α 1-acid glycoprotein , concentration dependence of the unbound drug fraction , equilibrium dissociation constant , equilibrium protein binding , equilibrium dissociation constant , multiple binding sites , naproxen , nonspecific binding , pharmacokinetics , protein binding kinetics , steady state volume of distribution , temperature dependence of protein binding , ultrafiltration , unbound drug fraction
The reaction of drug–protein binding is considered...
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